Falkenberg T, Mohammed A K, Henriksson B, Persson H, Winblad B, Lindefors N
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Neurosci Lett. 1992 Apr 13;138(1):153-6. doi: 10.1016/0304-3940(92)90494-r.
Enriched environment has been shown to enhance learning and memory and to induce morphological changes in the hippocampus. We report that rats housed in an enriched environment showed improved performance in the Morris water maze and decreased spontaneous motor activity. Exposure to behavioural tests increased expression of the mRNA that encodes brain-derived neurotrophic factor in the hippocampus. This was not seen when rats subjected to impoverished housing were tested suggesting that environmental history of the animal is of importance to induce expression of brain-derived neurotrophic factor in the hippocampus that may promote neuronal changes related to learning and memory.
丰富环境已被证明能增强学习和记忆，并在海马体中诱导形态变化。我们报告称，饲养在丰富环境中的大鼠在莫里斯水迷宫中表现出更好的成绩，且自发运动活动减少。接受行为测试会增加海马体中编码脑源性神经营养因子的mRNA的表达。当对饲养在贫瘠环境中的大鼠进行测试时，未观察到这种情况，这表明动物的环境经历对于诱导海马体中脑源性神经营养因子的表达很重要，而该因子可能促进与学习和记忆相关的神经元变化。
