Asiyo M N, Stefani F H
Department of Ocular Pathology, University of Munich Eye Hospital, FRG.
Ophthalmic Res. 1992;24(3):155-61. doi: 10.1159/000267162.
To our knowledge, this is the first pathologic report of interscleral collagen bundle changes occurring as well-defined spindleform lesions randomly interspersed within the sclera. The lesions were observed in an otherwise healthy 75-year-old man whose eye was enucleated because of a uveal malignant melanoma. There are few reports in the literature of focal scleral changes of a predominantly acid mucopolysaccharide nature. The entity we observed in this case differs from these reports by its spindleform appearance, random distribution (not overlying the melanoma) and predominantly vicinal glycol nature. Histopathologic, histochemical, and ultrastructural studies revealed that the lesions were not the result of mucoid degeneration of the scleral collagen and not an abnormal collagen structure.
据我们所知，这是首例关于巩膜内胶原束变化的病理报告，这些变化表现为界限清晰的梭形病变，随机散布于巩膜内。病变见于一名75岁身体健康的男性，其眼因葡萄膜恶性黑色素瘤而被摘除。文献中关于主要为酸性粘多糖性质的局灶性巩膜变化的报道很少。我们在该病例中观察到的病变与这些报道不同，其呈梭形外观、随机分布（不位于黑色素瘤上方）且主要为邻位二醇性质。组织病理学、组织化学和超微结构研究表明，这些病变不是巩膜胶原黏液样变性的结果，也不是异常的胶原结构。
