Ho A C, Lieb W E, Flaharty P M, Sergott R C, Brown G C, Bosley T M, Savino P J
Neuro-Ophthalmology Service, Wills Eye Hospital, Philadelphia, PA.
Ophthalmology. 1992 Sep;99(9):1453-62. doi: 10.1016/s0161-6420(92)31784-1.
This study describes hemodynamic characteristics of the ophthalmic, central retinal, and posterior ciliary arteries in 16 eyes of 11 patients with the ocular ischemic syndrome. Understanding the hemodynamic characteristics of the retrobulbar circulation may elucidate the natural history and pathophysiology of the ocular ischemic syndrome and perhaps form the basis for rational treatment of this condition.
Color Doppler imaging, a procedure that permits rapid noninvasive imaging of the ophthalmic, central retinal, and posterior ciliary arteries, was used to quantitate peak systolic blood flow velocities and vascular resistance (pulsatility index) within these vessels in study group eyes and in an age-matched control population.
We demonstrated markedly reduced ocular ischemic syndrome central retinal and posterior ciliary artery peak systolic velocities compared with control group eyes. Central retinal and posterior ciliary artery vascular resistance (pulsatility index) was greater in ocular ischemic eyes versus control group eyes. Reversal of ophthalmic artery blood flow was detected in 12 of 16 ocular ischemic syndrome eyes. Study group eyes with poor vision had no detectable posterior ciliary arterial blood flow.
Color Doppler imaging quantitates hemodynamic characteristics of the retrobulbar circulation in the ocular ischemic syndrome. There is markedly reduced peak systolic velocity and increased vascular resistance in ocular end arteries such as the central retinal and posterior ciliary arteries. Ophthalmic artery reversal of flow seems to represent collateral blood flow to lower resistance vascular beds. Posterior ciliary artery hypoperfusion may correlate with poor vision in the ocular ischemic syndrome.
本研究描述了11例患有眼部缺血综合征患者的16只眼中眼动脉、视网膜中央动脉和睫状后动脉的血流动力学特征。了解球后循环的血流动力学特征可能有助于阐明眼部缺血综合征的自然病程和病理生理学，或许还能为合理治疗该病奠定基础。
彩色多普勒成像可对眼动脉、视网膜中央动脉和睫状后动脉进行快速无创成像，该方法用于定量研究组眼中以及年龄匹配的对照组人群中这些血管内的收缩期峰值血流速度和血管阻力（搏动指数）。
我们发现，与对照组眼睛相比，眼部缺血综合征患者视网膜中央动脉和睫状后动脉的收缩期峰值速度明显降低。眼部缺血患者的视网膜中央动脉和睫状后动脉的血管阻力（搏动指数）高于对照组眼睛。在16只患有眼部缺血综合征的眼睛中，有12只检测到眼动脉血流逆转。视力差的研究组眼睛未检测到睫状后动脉血流。
彩色多普勒成像可定量眼部缺血综合征球后循环的血流动力学特征。视网膜中央动脉和睫状后动脉等眼内终末动脉的收缩期峰值速度明显降低，血管阻力增加。眼动脉血流逆转似乎代表了向低阻力血管床的侧支血流。睫状后动脉灌注不足可能与眼部缺血综合征患者的视力差有关。
