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无证据表明颈动脉疾病中视网膜血流减少会导致视网膜损伤进展。

No Evidence for Retinal Damage Evolving from Reduced Retinal Blood Flow in Carotid Artery Disease.

作者信息

Heßler Henning, Zimmermann Hanna, Oberwahrenbrock Timm, Kadas Ella Maria, Mikolajczak Janine, Brandt Alexander U, Kauert Andreas, Paul Friedemann, Schreiber Stephan J

机构信息

NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Department of Neurology, Königin-Elisabeth-Herzberge Hospital, 10365 Berlin, Germany.

出版信息

Biomed Res Int. 2015;2015:604028. doi: 10.1155/2015/604028. Epub 2015 Oct 19.

DOI:10.1155/2015/604028
PMID:26558275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4628976/
Abstract

INTRODUCTION

Carotid artery disease (CAD) comprising high-grade internal carotid artery stenosis (CAS) or carotid artery occlusion (CAO) may lead to ipsilateral impaired cerebral blood flow and reduced retinal blood supply.

OBJECTIVE

To examine the influence of chronic CAD on retinal blood flow, retinal morphology, and visual function.

METHODS

Patients with unilateral CAS ≥ 50% (ECST criteria) or CAO were grouped according to the grade of the stenosis and to the flow direction of the ophthalmic artery (OA). Retinal perfusion was measured by transorbital duplex ultrasound, assessing central retinal artery (CRA) blood flow velocities. In addition, optic nerve and optic nerve sheath diameter were measured. Optical coherence tomography (OCT) was performed to study retinal morphology. Visual function was assessed using high- and low-contrast visual paradigms.

RESULTS

Twenty-seven patients were enrolled. Eyes with CAS ≥ 80%/CAO and retrograde OA blood flow showed a significant reduction in CRA peak systolic velocity (no-CAD side: 0.130 ± 0.035 m/s, CAS/CAO side: 0.098 ± 0.028; p = 0.005; n = 12). OCT, optic nerve thicknesses, and visual functional parameters did not show a significant difference.

CONCLUSION

Despite assessable hemodynamic effects, chronic high-grade CAD does not lead to gaugeable morphological or functional changes of the retina.

摘要

引言

包括重度颈内动脉狭窄（CAS）或颈动脉闭塞（CAO）在内的颈动脉疾病（CAD）可能导致同侧脑血流受损和视网膜血液供应减少。

目的

研究慢性CAD对视网膜血流、视网膜形态和视觉功能的影响。

方法

将单侧CAS≥50%（欧洲颈动脉外科试验[ECST]标准）或CAO患者根据狭窄程度和眼动脉（OA）血流方向分组。通过经眶双功超声测量视网膜灌注，评估视网膜中央动脉（CRA）血流速度。此外，测量视神经和视神经鞘直径。进行光学相干断层扫描（OCT）以研究视网膜形态。使用高对比度和低对比度视觉范式评估视觉功能。

结果

纳入27例患者。CAS≥80%/CAO且OA血流逆行的眼CRA收缩期峰值速度显著降低（无CAD侧：0.130±0.035m/s，CAS/CAO侧：0.098±0.028；p = 0.005；n = 12）。OCT、视神经厚度和视觉功能参数未显示出显著差异。

结论

尽管存在可评估的血流动力学影响，但慢性重度CAD不会导致视网膜出现可测量的形态或功能变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/b1603a273907/BMRI2015-604028.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/84fe169c9297/BMRI2015-604028.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/8276878fe21d/BMRI2015-604028.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/b1603a273907/BMRI2015-604028.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/84fe169c9297/BMRI2015-604028.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/8276878fe21d/BMRI2015-604028.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752a/4628976/b1603a273907/BMRI2015-604028.003.jpg

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2
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3
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