Keyser B J, Flaharty P M, Sergott R C, Brown G C, Lieb W E, Annesley W H
Retina Service, Wills Eye Hospital, Jefferson Medical College, Philadelphia, PA 19107.
Ophthalmology. 1994 Aug;101(8):1357-61. doi: 10.1016/s0161-6420(94)31161-4.
The hemodynamics of the retrobulbar arterial circulation of patients with central retinal vein occlusion were evaluated in order to better understand the pathophysiology of this disease.
Color Doppler imaging was used to measure the peak systolic velocity and vascular resistance (pulsatility index) in the retrobulbar arteries of involved eyes and clinically healthy fellow eyes of patients with central retinal vein occlusion and in the control eyes of age- and sex-matched healthy volunteers.
Average peak systolic velocity was significantly lower and average vascular resistance was significantly higher in the central retinal artery of involved eyes of patients with central retinal vein occlusion compared with clinically healthy fellow eyes and compared with control eyes. There also was a trend toward higher vascular resistance in the central retinal artery of clinically healthy fellow eyes of patients with central retinal vein occlusion compared with control eyes. In the ophthalmic arteries and short posterior ciliary arteries, vascular resistance was significantly higher in both the involved eyes and clinically healthy fellow eyes of patients with central retinal vein occlusion compared with control eyes.
Color Doppler imaging parameters of the central retinal artery circulation were abnormal in eyes with central retinal vein occlusion, suggesting impaired arterial blood flow associated with this disease. The high vascular resistance in the central retinal arteries, ophthalmic arteries, and short posterior ciliary arteries of both involved and clinically healthy fellow eyes of patients with central retinal vein occlusion suggests that diffuse small vessel disease may predate and contribute to the development of central retinal vein occlusion.
评估视网膜中央静脉阻塞患者球后动脉循环的血流动力学，以更好地理解该疾病的病理生理学。
采用彩色多普勒成像测量视网膜中央静脉阻塞患者患眼及健侧眼的球后动脉的收缩期峰值流速和血管阻力（搏动指数），并测量年龄和性别匹配的健康志愿者的对照眼。
与健侧眼及对照眼相比，视网膜中央静脉阻塞患者患眼的视网膜中央动脉平均收缩期峰值流速显著降低，平均血管阻力显著升高。视网膜中央静脉阻塞患者健侧眼的视网膜中央动脉血管阻力也有高于对照眼的趋势。与对照眼相比，视网膜中央静脉阻塞患者患眼及健侧眼的眼动脉和睫状后短动脉的血管阻力均显著升高。
视网膜中央静脉阻塞患者的视网膜中央动脉循环的彩色多普勒成像参数异常，提示与该疾病相关的动脉血流受损。视网膜中央静脉阻塞患者患眼及健侧眼的视网膜中央动脉、眼动脉和睫状后短动脉的高血管阻力表明，弥漫性小血管疾病可能早于视网膜中央静脉阻塞出现并促进其发展。
