Burchard G D, Möslein C, Brattig N W
Bernhard Nocht Institute for Tropical Medicine, Clinical Department, Hamburg, Federal Republic of Germany.
Parasitol Res. 1992;78(4):336-40. doi: 10.1007/BF00937093.
Differentiation of promyelocytic HL-60 cells along the pathway toward granulocytes using dimethyl-sulfoxide (DMSO) led to increased expression of the adhesion molecules CD11b (Mac-1), CD11c (p150,95), and CD35 (CR1). Undifferentiated and differentiated HL-60 cells adhered similarly to Entamoeba histolytica trophozoites, and monoclonal antibodies against adhesion molecules CD11b and CD11c did not inhibit adherence. We therefore suggest that CD11b and CD11c are not involved in the adherence between polymorphonuclear granulocytes and E. histolytica trophozoites.
使用二甲基亚砜（DMSO）使早幼粒细胞HL - 60细胞沿粒细胞途径分化，导致黏附分子CD11b（Mac - 1）、CD11c（p150,95）和CD35（CR1）的表达增加。未分化和分化的HL - 60细胞与溶组织内阿米巴滋养体的黏附情况相似，并且针对黏附分子CD11b和CD11c的单克隆抗体不抑制黏附。因此，我们认为CD11b和CD11c不参与多形核粒细胞与溶组织内阿米巴滋养体之间的黏附。
