Macko V, Stimmel M B, Wolpert T J, Dunkle L D, Acklin W, Bänteli R, Jaun B, Arigoni D
Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.
Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9574-8. doi: 10.1073/pnas.89.20.9574.
Four metabolites named peritoxins A and B and periconins A and B have been isolated together with the known metabolite circinatin from culture filtrates of the fungal pathogen Periconia circinata. Peritoxins A and B, which correspond to the P. circinata toxins Ia and IIa partially characterized in previous work, are selectively toxic to genotypes of Sorghum bicolor susceptible to the pathogen, whereas periconins A and B are biologically inactive. Combination of instrumental analysis and chemical degradation has led to structural assignments for each of the four compounds; only the configuration at some of the chiral centers remains undefined. Structural comparison suggests a precursor role for circinatin in the formation of the peritoxins and the periconins.
从真菌病原体圆形梨孢（Periconia circinata）的培养滤液中分离出了四种代谢产物，分别命名为梨孢毒素A和B以及梨孢菌素A和B，同时还分离出了已知的代谢产物环孢菌素。梨孢毒素A和B分别对应于先前工作中部分鉴定的圆形梨孢毒素Ia和IIa，它们对该病原体敏感的高粱（Sorghum bicolor）基因型具有选择性毒性，而梨孢菌素A和B则无生物活性。通过仪器分析和化学降解相结合的方法，确定了这四种化合物各自的结构；只有部分手性中心的构型尚未确定。结构比较表明，环孢菌素在梨孢毒素和梨孢菌素的形成过程中起前体作用。
