Amass L, Nardin R, Mendelson J H, Teoh S K, Woods B T
Department of Psychiatry, University of Vermont School of Medicine, Burlington 05401.
Psychiatry Res. 1992 May;45(1):15-23. doi: 10.1016/0925-4927(92)90010-2.
Quantitative magnetic resonance imaging (MRI) of the brain was performed in nine drug-dependent men with a primary diagnosis of opioid and/or cocaine dependence, and 10 age-matched, non-drug-dependent controls. Individuals were screened for the presence of gross cerebral abnormalities before T1 and T2 analyses. Regional T1 and T2 times were calculated on a single 5-mm thick axial slice positioned just below the caudal margin of the lateral ventricles, passing through the caudate and putamen. A voxel of interest (VOI) cursor was placed bilaterally within the putamen, caudate, frontal gray matter, frontal white matter, or posterior white matter. T1 and T2 values were determined for each VOI using an iterative chi 2 minimization program. T1 and T2 relaxation times did not differ significantly between the subject groups in any brain region studied. These results suggest that T1 and T2 relaxation times may not identify microstructural central nervous system changes resulting from chronic opiate and cocaine abuse.
对9名初步诊断为阿片类药物和/或可卡因依赖的药物依赖男性以及10名年龄匹配的非药物依赖对照者进行了脑部定量磁共振成像（MRI）检查。在进行T1和T2分析之前，对个体进行了大脑明显异常情况的筛查。在位于侧脑室尾缘下方、穿过尾状核和壳核的单个5毫米厚轴位切片上计算区域T1和T2时间。在双侧壳核、尾状核、额叶灰质、额叶白质或后白质内放置感兴趣体素（VOI）光标。使用迭代卡方最小化程序确定每个VOI的T1和T2值。在所研究的任何脑区中，受试者组之间的T1和T2值均无显著差异。这些结果表明，T1和T2弛豫时间可能无法识别慢性阿片类药物和可卡因滥用导致的中枢神经系统微观结构变化。
