Jacobsen L K, Giedd J N, Gottschalk C, Kosten T R, Krystal J H
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
Am J Psychiatry. 2001 Mar;158(3):486-9. doi: 10.1176/appi.ajp.158.3.486.
Deficits in dopaminergic function may contribute to hypertrophy of striatal structures associated with typical neuroleptic treatment. In light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence.
Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25 cocaine-dependent and 20 healthy subjects.
Normalized caudate and putamen volumes were 3.40% and 9.18% larger, respectively, in the cocaine-dependent subjects.
These observations suggest that deficits in dopaminergic function associated with cocaine dependence may contribute to striatal hypertrophy.
多巴胺能功能缺陷可能导致与典型抗精神病药物治疗相关的纹状体结构肥大。鉴于一系列将长期使用可卡因与锥体外系症状及纹状体多巴胺能耗竭相关联的研究，作者探寻慢性可卡因依赖患者纹状体形态异常的证据。
通过磁共振成像对25名可卡因依赖者和20名健康受试者的尾状核、壳核及全脑体积进行量化。
可卡因依赖者的尾状核和壳核标准化体积分别比健康受试者大3.40%和9.18%。
这些观察结果表明，与可卡因依赖相关的多巴胺能功能缺陷可能导致纹状体肥大。
