POTTER J L, O'BRIEN R D
Science. 1964 Apr 3;144(3614):55-7. doi: 10.1126/science.144.3614.55.
Liver slices from seven terrestrial and six aquatic animals studied "activated" parathion, converting it to paraoxon, a potent anticholinesterase. Although there are similarities between the liver systems which activate parathion and which degrade drugs such as aminopyrine and phenacetin, liver slices of aquatic vertebrates can activate parathion but cannot degrade such drugs.
对七种陆生动物和六种水生动物的肝脏切片进行研究，发现其能“激活”对硫磷，将其转化为对氧磷，一种强效抗胆碱酯酶。虽然激活对硫磷的肝脏系统与降解氨基比林和非那西丁等药物的肝脏系统存在相似之处，但水生脊椎动物的肝脏切片能激活对硫磷，却不能降解这类药物。
