Soskolne C L, Jhangri G S, Siemiatycki J, Lakhani R, Dewar R, Burch J D, Howe G R, Miller A B
Department of Health Services Administration and Community Medicine, Faculty of Medicine, University of Alberta, Edmonton, Canada.
Scand J Work Environ Health. 1992 Aug;18(4):225-32. doi: 10.5271/sjweh.1585.
A case-referent study, designed to test associations between asbestos, nickel, and the development of laryngeal cancer, was conducted in southern Ontario in 1977-1979. The cases were individually matched to neighborhood referents for gender and age. This constituted the primary study. Personal interviews had secured tobacco, alcohol, and detailed work histories. To 183 of the male pairs was added retrospective assessments of sulfuric acid exposure for each job, blind of disease status; this constituted the data base for an augmented secondary analysis. Logistic regression revealed statistically significant odds ratios when tobacco and alcohol were controlled. Exposure-response gradients were strongly positive with odds ratios in the range of 1.97 [95% confidence interval (95% CI) 0.63-6.13] for short duration-low level exposure through 6.91 [95% CI 2.20-21.74] for long duration-higher level exposure employing progressively more specific definitions of exposure. Asbestos as a confounder and the interaction terms examined were nonsignificant. These findings are corroborative of those of other studies.
1977年至1979年在安大略省南部开展了一项病例对照研究，旨在检测石棉、镍与喉癌发病之间的关联。病例按性别和年龄与邻里对照个体进行匹配。这构成了主要研究。通过个人访谈获取了吸烟、饮酒及详细的工作史。对183对男性研究对象，在不了解疾病状况的情况下，增加了对每份工作硫酸暴露情况的回顾性评估；这构成了增强型二次分析的数据库。在控制了吸烟和饮酒因素后，逻辑回归显示出具有统计学意义的优势比。暴露-反应梯度呈强正相关，短期低水平暴露的优势比为1.97[95%置信区间（95%CI）0.63 - 6.13]，长期高水平暴露的优势比为6.91[95%CI 2.20 - 21.74]，采用了逐步更具体的暴露定义。石棉作为混杂因素以及所检测的交互作用项均无统计学意义。这些发现与其他研究结果相符。
