Bättig K
Laboratorium für Verhaltensbiologie, Eidgenössische Technische Hochschule Zürich.
Schweiz Med Wochenschr. 1992 Oct 10;122(41):1536-43.
Whereas the earlier literature contains several studies on the acute cardiovascular effects of caffeine, systematic studies of the cardiovascular effects of regular daily coffee consumption have appeared only recently. Acute caffeine administration (total daily amount in one dose following caffeine abstinence) increases both systolic and diastolic blood pressures by 10-15 mm Hg and lowers the pulse by about 2-5 beats/min. Repeated caffeine administration leads to a rapid decline in the blood pressure response. Chronic switching between decaffeinated and caffeine-containing coffee showed no more than marginal changes in blood pressure. Plasma lipids are probably independent of caffeine consumption, but increase slightly with boiled (compared with filter) coffee. The question of the thermogenic effect of coffee consumption remains open. The prevalence of coronary disease appears to be epidemiologically independent of coffee consumption.
虽然早期文献中有几项关于咖啡因对心血管急性影响的研究,但关于日常规律饮用咖啡对心血管影响的系统性研究直到最近才出现。急性给予咖啡因(在戒断咖啡因后一次给予一日总量)可使收缩压和舒张压均升高10 - 15毫米汞柱,并使脉搏降低约2 - 5次/分钟。重复给予咖啡因会导致血压反应迅速下降。在无咖啡因咖啡和含咖啡因咖啡之间长期交替饮用,血压变化不超过轻微波动。血浆脂质可能与咖啡因摄入无关,但与煮咖啡(与过滤咖啡相比)有关,会略有增加。饮用咖啡的产热效应问题仍未明确。从流行病学角度看,冠心病的患病率似乎与咖啡饮用无关。