Burr M L, Gallacher J E, Butland B K, Bolton C H, Downs L G
MRC Epidemiology Unit, Cardiff, UK.
Eur J Clin Nutr. 1989 Jul;43(7):477-83.
A randomized controlled trial was conducted to examine the effects of coffee (as commonly drunk in Britain) on blood pressure and plasma lipids in healthy subjects. Fifty-four subjects followed three regimens successively, the order being randomized according to a Latin square design: five or more cups of coffee daily for 4 weeks; five or more cups of decaffeinated coffee daily for 4 weeks but no ordinary coffee; no coffee for 4 weeks. Coffee appeared to cause a small rise (of 3 mm Hg) in recumbent systolic blood pressure; this effect was less than, and obscured by, changes induced by posture and mild stress. No consistent changes attributable to coffee were found in diastolic blood pressure or pulse rate. Small changes in the expected directions occurred in plasma high density lipoprotein (HDL) cholesterol and apolipoprotein AI (decrease), and in total cholesterol, non-HDL cholesterol and apolipoprotein B (increase), but none of these were statistically significant. The effect of coffee on risk of heart disease in Britain is probably small.
一项随机对照试验旨在研究咖啡（如英国人日常饮用的那种）对健康受试者血压和血脂的影响。54名受试者依次遵循三种方案，顺序根据拉丁方设计随机安排：每天饮用五杯或更多咖啡，持续4周；每天饮用五杯或更多脱咖啡因咖啡，持续4周，但不饮用普通咖啡；4周不喝咖啡。咖啡似乎会使卧位收缩压小幅升高（3毫米汞柱）；这种影响小于姿势和轻度压力引起的变化，并被其掩盖。在舒张压或脉搏率方面未发现可归因于咖啡的一致变化。血浆高密度脂蛋白（HDL）胆固醇和载脂蛋白AI出现了预期方向的小幅变化（下降），总胆固醇、非HDL胆固醇和载脂蛋白B出现了小幅变化（上升），但这些均无统计学意义。在英国，咖啡对心脏病风险的影响可能较小。
