Vale R D
Department of Pharmacology, University of California, San Francisco 94143.
Trends Biochem Sci. 1992 Aug;17(8):300-4. doi: 10.1016/0968-0004(92)90440-k.
A far greater variety of microtubule-based motors populate the interior of most eukaryotic cells than was ever imagined, and the inventory of these proteins is growing each year. The discovery of new motors, however, has raised many questions of how cells use their arsenal of force-generating machines. The ability to apply genetics, bacterial expression, biochemistry and in vitro motility assays to study motor proteins provides new opportunities for examining these problems at a molecular level.
在大多数真核细胞内部，基于微管的马达种类之多远超以往想象，而且这类蛋白质的清单每年都在增加。然而，新马达的发现引发了许多关于细胞如何利用其一系列产生力的机器的问题。运用遗传学、细菌表达、生物化学以及体外运动分析来研究马达蛋白的能力，为在分子水平上研究这些问题提供了新的机会。
