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氧气对结核分枝杆菌生长的抑制作用

OXYGEN INHIBITION OF GROWTH OF MYCOBACTERIUM TUBERCULOSIS.

作者信息

GOTTLIEB S F, ROSE N R, MAURIZI J, LANPHIER E H

出版信息

J Bacteriol. 1964 Apr;87(4):838-43. doi: 10.1128/jb.87.4.838-843.1964.

Abstract

Gottlieb, S. F. (Linde Division, Union Carbide Corporation, Tonawanda, N.Y.), Noel R. Rose, Jerome Maurizi, and Edward H. Lanphier. Oxygen inhibition of growth of Mycobacterium tuberculosis. J. Bacteriol. 87:838-843. 1964.-Continuous or intermittent exposure to 3 atm of oxygen in the presence or absence of 40 mm of Hg CO(2) resulted in marked delay or inhibition of growth of Mycobacterium tuberculosis. This inhibition was more pronounced with newly inoculated cultures, as compared to young, actively growing cultures. Oxygen inhibition of growth was observed on both Lowenstein-Jensen and blood agar media. Bacteriostatic effects of oxygen are a direct function of exposure time. A more marked effect of oxygen was observed in the presence of isoniazid, streptomycin, or p-aminosalicyclic acid.

摘要

戈特利布,S.F.(联合碳化物公司林德分部,纽约州托纳旺达),诺埃尔·R.罗斯,杰罗姆·毛里齐,以及爱德华·H.兰菲尔。氧气对结核分枝杆菌生长的抑制作用。《细菌学杂志》87:838 - 843。1964年。——在有或无40毫米汞柱二氧化碳存在的情况下,持续或间歇暴露于3个大气压的氧气会导致结核分枝杆菌生长显著延迟或受到抑制。与年轻、活跃生长的培养物相比,新接种的培养物受到的这种抑制更为明显。在罗 - 琴培养基和血琼脂培养基上均观察到氧气对生长的抑制作用。氧气的抑菌作用是暴露时间的直接函数。在异烟肼、链霉素或对氨基水杨酸存在的情况下,观察到氧气的作用更为显著。

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