异烟肼处理结核分枝杆菌H37Ra提取物产生活性氧的证据。
Evidence for the generation of active oxygen by isoniazid treatment of extracts of Mycobacterium tuberculosis H37Ra.
作者信息
Shoeb H A, Bowman B U, Ottolenghi A C, Merola A J
出版信息
Antimicrob Agents Chemother. 1985 Mar;27(3):404-7. doi: 10.1128/AAC.27.3.404.
Abstract
Crude extracts of Mycobacterium tuberculosis H37Ra, an isonicotinic acid hydrazide (isoniazid) (INH)-susceptible strain which has peroxidase activity, catalyzed the production of catechol from phenol in the presence of INH and H2O2 as shown by the development of the 444-nm absorption peak of oxidized catechol product. Extracts of the INH-resistant strain of M. tuberculosis H37Ra, which has no peroxidase, did not catalyze the reaction. The rate of development of the 444-nm peak increased proportionately with increased superoxide dismutase concentrations. The hydroxyl radical (. OH) scavengers dimethylsulfoxide and mannitol inhibited the reaction. Isonicotinamide, isonicotinic acid, and nicotinic acid could not replace INH.
摘要
结核分枝杆菌H37Ra的粗提物是一种对异烟肼（INH）敏感且具有过氧化物酶活性的菌株，在INH和H2O2存在的情况下，它能催化苯酚生成邻苯二酚，这可通过氧化邻苯二酚产物在444nm处吸收峰的出现得以证明。没有过氧化物酶的耐INH结核分枝杆菌H37Ra菌株的提取物则不能催化该反应。444nm峰的出现速率随超氧化物歧化酶浓度的增加而成比例增加。羟基自由基（·OH）清除剂二甲亚砜和甘露醇可抑制该反应。异烟酰胺、异烟酸和烟酸不能替代INH。
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本文引用的文献
1
OXYGEN INHIBITION OF GROWTH OF MYCOBACTERIUM TUBERCULOSIS.氧气对结核分枝杆菌生长的抑制作用
J Bacteriol. 1964 Apr;87(4):838-43. doi: 10.1128/jb.87.4.838-843.1964.
2
Catalase and peroxidase in mycobacteria. Possible relationship to the mode of action of isoniazid.分枝杆菌中的过氧化氢酶和过氧化物酶。与异烟肼作用方式的可能关系。
Am Rev Respir Dis. 1960 Jan;81:68-78. doi: 10.1164/arrd.1960.81.1P1.68.
3
The effect of isoniazid on growing and resting tubercle bacilli.异烟肼对生长中和静止期结核杆菌的作用。
Am Rev Tuberc. 1954 Jan;69(1):125-7. doi: 10.1164/art.1954.69.1.125.
4
The susceptibility of strains of Mycobacterium tuberculosis to catalase-mediated peroxidative killing.
J Gen Microbiol. 1980 Dec;121(2):381-6. doi: 10.1099/00221287-121-2-381.
5
Superoxide anion generated by potassium superoxide is cytotoxic and mutagenic to chinese hamster ovary cells.
Mutat Res. 1983 Sep;121(3-4):299-304. doi: 10.1016/0165-7992(83)90218-x.
6
Superoxide-dependent formation of hydroxyl radicals: detection of hydroxyl radicals by the hydroxylation of aromatic compounds.超氧化物依赖性羟自由基的形成：通过芳香族化合物的羟基化检测羟自由基。
Anal Biochem. 1981 Dec;118(2):328-35. doi: 10.1016/0003-2697(81)90590-x.
7
Media and methods for phage-typing mycobacteria.用于分枝杆菌噬菌体分型的培养基和方法。
Bull World Health Organ. 1966;35(4):563-8.
8
Response of Mycobacteria to ultraviolet light radiation.分枝杆菌对紫外线辐射的反应。
Am Rev Respir Dis. 1973 Nov;108(5):1175-85. doi: 10.1164/arrd.1973.108.5.1175.
9
Peroxidase-mediated oxidation of isoniazid.过氧化物酶介导的异烟肼氧化反应。
Antimicrob Agents Chemother. 1985 Mar;27(3):399-403. doi: 10.1128/AAC.27.3.399.
10
Enzymatic and nonenzymatic superoxide-generating reactions of isoniazid.异烟肼的酶促和非酶促超氧化物生成反应。
Antimicrob Agents Chemother. 1985 Mar;27(3):408-12. doi: 10.1128/AAC.27.3.408.
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