Kato S, Hirano A, Kato M, Herz F, Ohama E
Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Acta Neuropathol. 1992;84(3):261-4. doi: 10.1007/BF00227818.
This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.
本报告探讨了应激反应（热休克）蛋白72（srp 72）在95例原发性人脑肿瘤及21例中枢神经系统（CNS）癌转移瘤中的表达情况。采用免疫组织化学方法；人宫颈癌HeLa S3细胞系作为阳性对照。在14/22例脑膜瘤和6/13例胶质母细胞瘤中检测到该蛋白。在4/17例星形细胞瘤、2/9例垂体瘤、2/14例原始神经外胚层肿瘤和1/10例髓母细胞瘤中也发现了表达srp 72的肿瘤细胞。大多数（8/10）乳腺癌转移瘤有表达srp 72的肿瘤细胞，而只有2/11例肺肿瘤转移瘤呈阳性染色。这些结果证明了srp 72在多种原发性和转移性CNS肿瘤中的表达。
