Ohta H, Uji Y, Hattori Y, Sugimoto M, Higuchi K
Department of Ophthalmology, Mie University School of Medicine, Tsu, Japan.
Nippon Ganka Gakkai Zasshi. 1992 Sep;96(9):1148-53.
The author reviewed the seasonal variation of intraocular pressure (IOP) in primary open angle glaucoma or late type developmental glaucoma to investigate possible relationships among seasonal variation of IOP, progression of visual field defects and the follow-up period between 53 eyes of 39 subjects with successful trabeculotomy (trabeculotomy group) and 45 eyes of 31 subjects with only medication (no operation group). IOPs in both groups were inclined to be low in summer and high in winter. Maximum seasonal variation of IOP and standard deviation of IOP during all follow-up periods which showed the degree of seasonal variation of IOP had no significant difference between the trabeculotomy group and the no operation group. These results showed that seasonal variation of IOP was not reduced even by successful trabeculotomy. The maximum seasonal variation of IOP and standard deviation of IOP had a tendency to be bigger in cases with progression of visual field defects than in cases with no progression of visual field defects, in both groups. Therefore, seasonal variation of IOP may be an important factor influencing the progression of visual field defects.
作者回顾了原发性开角型青光眼或晚期发育性青光眼患者眼内压（IOP）的季节性变化，以研究IOP的季节性变化、视野缺损进展以及39例小梁切开术成功的患者（小梁切开术组）的53只眼和31例仅接受药物治疗的患者（未手术组）的45只眼之间随访期的可能关系。两组的IOP均倾向于夏季较低，冬季较高。小梁切开术组和未手术组之间，IOP的最大季节性变化以及所有随访期内IOP的标准差（显示IOP季节性变化程度）无显著差异。这些结果表明，即使小梁切开术成功，IOP的季节性变化也不会降低。两组中，视野缺损进展的病例与视野缺损未进展的病例相比，IOP的最大季节性变化和IOP的标准差往往更大。因此，IOP的季节性变化可能是影响视野缺损进展的一个重要因素。
