Ito A, Itoh Y, Sasaguri Y, Morimatsu M, Mori Y
Department of Biochemistry, Tokyo College of Pharmacy, Japan.
Arthritis Rheum. 1992 Oct;35(10):1197-201. doi: 10.1002/art.1780351012.
High levels of interleukin-6 (IL-6) have been found in the synovial fluid of patients with rheumatoid arthritis (RA). We undertook the present study to investigate the role of IL-6 in this disease.
We examined the effects of IL-6, in comparison with IL-1, on the biosynthesis of extracellular matrix macromolecules and of matrix-degrading proteinases in rheumatoid synovial fibroblasts.
In rheumatoid synovial fibroblasts, IL-6 by itself enhanced the production of plasminogen activator, its inhibitor, and tissue inhibitor of metalloproteinases, whereas it did not modulate the biosynthesis of precursor of matrix metalloproteinase 1 (proMMP-1) (tissue collagenase), proMMP-3 (stromelysin), or connective tissue components. However, IL-1-induced production of proMMP-1 and proMMP-3 was preferentially augmented by IL-6.
These results suggest that in RA, IL-6 may participate along with IL-1 in fine tuning of the catabolism of connective tissue components, by modulating the balance between connective tissue-degrading enzymes and their inhibitors.
在类风湿性关节炎（RA）患者的滑液中发现了高水平的白细胞介素-6（IL-6）。我们开展本研究以调查IL-6在该疾病中的作用。
我们将IL-6与IL-1相比较，研究其对类风湿性滑膜成纤维细胞中细胞外基质大分子和基质降解蛋白酶生物合成的影响。
在类风湿性滑膜成纤维细胞中，IL-6自身可增强纤溶酶原激活物、其抑制剂以及金属蛋白酶组织抑制剂的产生，而它并不调节基质金属蛋白酶1（proMMP-1）（组织胶原酶）、proMMP-3（基质溶解素）或结缔组织成分前体的生物合成。然而，IL-6可优先增强IL-1诱导的proMMP-1和proMMP-3的产生。
这些结果表明，在RA中，IL-6可能与IL-1一起通过调节结缔组织降解酶及其抑制剂之间的平衡，参与结缔组织成分分解代谢的精细调节。
