Bednarík T, Májský A, Simek L, Cajthamlová H, Vopatová M
Allerg Immunol (Leipz). 1977;23(1):43-6.
The possible utilization of the effect of immunological tolerance for inhibition of formation of thromboagglutinins was studied, which dependent of the kind of antigen employed for immunization more or less contaminate antilymphocyte sera (ALS) or globulins (ALG). In the sera of pigs weighing 80-90 kg, immunized with human thrombocytes the thromboagglutinin levels in a) animals tolerated in adult age with an i.v. dose of 2.2 X 10(9) thrombocytes though the complete inhibition of thromboagglutinin formation failed even in these conditions. The attempted induction of tolerance in adult animals, similarly as in newborn piglets obtaining a dose of 1 X 10(9) thrombocytes, was of little success. Good results were recorded in animals tolerated in the perinatal period with a dose of 5 X 10(9) thrombocytes though the complete inhibition of thromboagglutinin formation failed even in these conditions. The authors suggest that of all possible methods for thromboagglutinin elimination, for ALS production the above technique, i.e. the induction of tolerance during the perinatal period seems most feasible, both from the viewpoint of effectiveness and thrombocyte consumption as well.
研究了利用免疫耐受作用抑制血栓凝集素形成的可能性，这或多或少取决于用于免疫的抗原种类，会污染抗淋巴细胞血清（ALS）或球蛋白（ALG）。在体重80 - 90公斤的猪血清中，用人类血小板免疫后，a）成年时经静脉注射2.2×10⁹个血小板而产生耐受性的动物，其血栓凝集素水平，即使在这些条件下也未能完全抑制血栓凝集素的形成。在成年动物中诱导耐受性，与给新生仔猪注射1×10⁹个血小板的情况类似，收效甚微。在围产期经5×10⁹个血小板产生耐受性的动物中取得了良好结果，即使在这些条件下也未能完全抑制血栓凝集素的形成。作者认为，从有效性和血小板消耗的角度来看，在所有可能的消除血栓凝集素的方法中，上述用于生产ALS的技术，即在围产期诱导耐受性似乎是最可行的。
