饥饿和实验性糖尿病对豚鼠磷酸烯醇丙酮酸羧激酶的影响。
The effects of starvation and experimental diabetes on phosphoenol-pyruvate carboxykinase in the guinea pig.
作者信息
Elliott K R, Pogson C I
出版信息
Biochem J. 1977 May 15;164(2):357-61. doi: 10.1042/bj1640357.
Abstract
- Approx. 85% of liver phosphoenolpyruvate carboxykinase is associated with the mitochondrial fraction in the fed guinea pig. Enzyme activity is unchanged in diabetes, but doubles during starvation. In contrast with earlier reports, both cytoplasmic and mitochondrial activities were found to be increased. 2. In kidney cortex, total enzyme activity is increased in both starved and diabetic animals. These changes are associated with increases in the cytoplasmic activity alone. 3. In diabetic animals the mean blood-glucose concentration was 23.1 mM. Other blood metabolites were lower than those in the rat, and the animals did not show significant ketosis. 4. Changes in the rates of gluconeogenesis from lactate and propionate paralleled those in phosphoenolpyruvate carboxykinase activity.
摘要
- 在喂食状态的豚鼠中，肝脏磷酸烯醇式丙酮酸羧激酶约85%与线粒体部分相关。酶活性在糖尿病状态下不变，但在饥饿时翻倍。与早期报告相反，发现细胞质和线粒体活性均增加。2. 在肾皮质中，饥饿和糖尿病动物的总酶活性均增加。这些变化仅与细胞质活性的增加相关。3. 糖尿病动物的平均血糖浓度为23.1 mM。其他血液代谢物低于大鼠，且动物未表现出明显的酮血症。4. 乳酸和丙酸糖异生速率的变化与磷酸烯醇式丙酮酸羧激酶活性的变化平行。
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