Chen C J, Chen C W, Wu M M, Kuo T L
Institute of Public Health, National Taiwan University College of Medicine, Taipei, ROC.
Br J Cancer. 1992 Nov;66(5):888-92. doi: 10.1038/bjc.1992.380.
In order to compare risk of various internal organ cancers induced by ingested inorganic arsenic and to assess the differences in risk between males and females, cancer potency indices were calculated using mortality rates among residents in an endemic area of chronic arsenicism on the southwest coast of Taiwan, and the Armitage-Doll multistage model. Based on a total of 898,806 person-years as well as 202 liver cancer, 304 lung cancer, 202 bladder cancer and 64 kidney cancer deaths, a significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers. The potency index of developing cancer of the liver, lung, bladder and kidney due to an intake of 10 micrograms kg day of arsenic was estimated as 4.3 x 10(-3), 1.2 x 10(-2), 1.2 x 10(-2), and 4.2 x 10(-3), respectively, for males; as well as 3.6 x 10(-3), 1.3 x 10(-2), 1.7 x 10(-2), and 4.8 x 10(-3), respectively, for females in the study area. The multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.
为了比较摄入无机砷诱发各种内脏器官癌症的风险，并评估男性和女性在风险上的差异，利用台湾西南海岸慢性砷中毒流行地区居民的死亡率以及阿米蒂奇 - 多尔多阶段模型计算癌症效力指数。基于总共898,806人年以及202例肝癌、304例肺癌、202例膀胱癌和64例肾癌死亡病例，观察到饮用水中砷含量与这些癌症的死亡率之间存在显著的剂量反应关系。对于男性，因每日摄入10微克/千克砷而患肝癌、肺癌、膀胱癌和肾癌的效力指数估计分别为4.3×10⁻³、1.2×10⁻²、1.2×10⁻²和4.2×10⁻³；在研究区域，女性的相应效力指数分别为3.6×10⁻³、1.3×10⁻²、1.7×10⁻²和4.8×10⁻³。无机砷诱发致癌作用的多效性且无任何器官特异性值得进一步研究。
