Baarsma R, Hof P, Zijlstra W G, Zock J P, Okken A
Department of Pediatrics, University Hospital Groningen, The Netherlands.
Biol Neonate. 1992;62(2-3):108-12. doi: 10.1159/000243862.
D2O and H2(18)O are often used as tracers for the determination of total body water (TBW). For newborn infants, the commonly used noninvasive method has not been validated. In this study TBW was calculated from D2O concentrations in blood and compared with TBW calculated from D2O concentrations in urine. TBW calculated from all urine portions voided at least 6 h after D2O administration on average was 1.0% lower. TBW calculated from only three urine portions voided 6, 12, and 24 h after D2O administration was 0.6% (mean) lower compared to TBW calculated from D2O concentrations in blood. This study indicates that the noninvasive method to measure TBW can be considered a reliable method when used in newborn infants.
重水（D2O）和水（H2(18)O）常被用作测定总体水（TBW）的示踪剂。对于新生儿，常用的非侵入性方法尚未得到验证。在本研究中，通过血液中的D2O浓度计算TBW，并与通过尿液中的D2O浓度计算的TBW进行比较。平均而言，从给予D2O后至少6小时排出的所有尿液部分计算得出的TBW低1.0%。与根据血液中D2O浓度计算的TBW相比，仅从给予D2O后6、12和24小时排出的三份尿液计算得出的TBW平均低0.6%。本研究表明，测量TBW的非侵入性方法在用于新生儿时可被视为一种可靠的方法。
