Endres H G, Grüner O
Institut für Klinische Pharmakologie, Klinik für Innere Medizin, Friedrich-Schiller-Universität, Jena, Germany.
Clin Investig. 1994 Nov;72(11):830-7. doi: 10.1007/BF00190736.
Total body water was measured by ethanol dilution and D2O stable isotope dilution in a group of 20 healthy volunteers (5 females and 15 males), predominantly 23- to 31-year-old students. Both indicator substances were given orally with an ethanol burden of 0.8 g/kg body weight and a D2O burden of 0.1 g/kg body weight after 12-h food and fluid restriction. This first direct comparison of total body water (TBW) from ethanol and D2O dilutions revealed the ethanol compartments to be smaller than those of D2O. The quotient of TBW (ethanol)/TBW (D2O) was 97.7%, which is the order of the quotient TBW (H2(18)O)/TBW (D2O) ( = 97%), well known from the literature and taken to represent relatively exactly the value of TBW overestimation (based on H/D exchange for acid protons) following D2O dilution [36]. Thus the value of TBW (ethanol) is almost identical to that of H2(18)O, which provides direct evidence that ethanol is distributed only in the body water.
在一组20名健康志愿者（5名女性和15名男性，主要是23至31岁的学生）中，通过乙醇稀释法和重水（D2O）稳定同位素稀释法测量了总体水含量。在禁食禁水12小时后，两种指示物质均经口服给予，乙醇负荷量为0.8 g/kg体重，重水负荷量为0.1 g/kg体重。首次对乙醇稀释法和重水稀释法测得的总体水（TBW）进行直接比较，结果显示乙醇分布容积小于重水分布容积。TBW（乙醇）/TBW（重水）的商为97.7%，这与文献中已知的TBW（H2(18)O）/TBW（重水）（ = 97%）的商处于同一水平，该商被认为相对准确地代表了重水稀释后总体水高估的值（基于酸性质子的H/D交换）[36]。因此，TBW（乙醇）的值几乎与H2(18)O的值相同，这直接证明了乙醇仅分布于体内的水中。
