Bhattacharyya M, Ghosh A N, Chaudhuri U, Poddar R K
Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, India.
Biophys Chem. 1992 Oct;44(3):209-17. doi: 10.1016/0301-4622(92)80053-8.
Normal human hemoglobin exceeding a certain minimum concentration (called critical aggregation concentration) undergoes aggregation in presence of the psychotherapeutic drug chlorpromazine (CPZ). The critical aggregation concentration decreases with the increase of CPZ concentration. Electron micrographs of CPZ-treated hemoglobin clearly indicate that the aggregates of hemoglobin are in filamentous form of average width 75 +/- 8 A. A possible mechanism for such aggregation has been discussed.
正常人体血红蛋白超过一定的最低浓度（称为临界聚集浓度）后，在精神治疗药物氯丙嗪（CPZ）存在的情况下会发生聚集。临界聚集浓度随CPZ浓度的增加而降低。经CPZ处理的血红蛋白的电子显微镜照片清楚地表明，血红蛋白聚集体呈丝状，平均宽度为75 +/- 8埃。已经讨论了这种聚集的一种可能机制。
