LEVINE B B, PRICE V H
Immunology. 1964 Sep;7(5):542-56.
Forty-one patients with acceptable past histories of allergic reactions to benzylpenicillin (PG), eleven patients with questionable histories to PG and thirty patients without past histories of allergic reactions to PG were skin tested with various multivalent haptenic conjugates and with simple chemicals derived from PG in order to determine the antigenic specificities of penicillin hypersensitivity of the wheal-and-flare type. The benzylpenicilloyl (BPO) group was found to be the major haptenic determinant of wheal-and-flare type PG hypersensitivity. Twenty-nine per cent of patients with acceptable histories of PG allergy and 3 per cent of patients without histories of PG allergy gave positive wheal-and-flare reactions to multivalent BPO-conjugates. Three patients who had unusual clinical forms of PG allergic reactions demonstrated patterns of wheal-and-flare reactivity indicating D-penicillamine or D-benzylpenamaldic acid disulphide haptenic specificity. No unequivocal wheal-and-flare reactivity specific for the benzylpenicillenic acid haptenic group was observed in this study. Data were obtained which indicate that BPO-specific wheal-and-flare skin reactivity demonstrates specificity for the entire large BPO haptenic group, and also for structural areas of the immunizing autologous hapten-carrier protein (i.e. carrier specificity).
41例有可接受的苄青霉素（PG）过敏既往史的患者、11例PG过敏史存疑的患者以及30例无PG过敏既往史的患者，接受了多种多价半抗原结合物以及源自PG的简单化学物质的皮肤试验，以确定风团和潮红型青霉素超敏反应的抗原特异性。发现苄青霉素酰（BPO）基团是风团和潮红型PG超敏反应的主要半抗原决定簇。29%有可接受的PG过敏史的患者和3%无PG过敏史的患者对多价BPO结合物出现了阳性风团和潮红反应。3例有不寻常PG过敏反应临床形式的患者表现出风团和潮红反应模式，提示D-青霉胺或D-苄青霉素醛酸二硫化物半抗原特异性。本研究中未观察到对苄青霉素酸半抗原基团明确的风团和潮红反应性。获得的数据表明，BPO特异性风团和潮红皮肤反应性对整个大的BPO半抗原基团以及免疫自体半抗原-载体蛋白的结构区域均表现出特异性（即载体特异性）。
