大鼠视交叉上核中血管加压素含量的昼夜节律。
Circadian rhythms of vasopressin content in the suprachiasmatic nucleus of the rat.
作者信息
Tominaga K, Shinohara K, Otori Y, Fukuhara C, Inouye S T
机构信息
Laboratory of Integrative Brain Functions, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
出版信息
Neuroreport. 1992 Sep;3(9):809-12. doi: 10.1097/00001756-199209000-00022.
The suprachiasmatic nucleus (SCN) of the anterior hypothalamus contains a circadian pacemaker in mammals. We determined the circadian profiles of arginine-vasopressin (AVP), a major peptide in the dorsomedial SCN, in rats under light-dark (LD), constant dark (DD) and constant light (LL) conditions. Under LD conditions, AVP levels in the SCN showed circadian rhythmicity with a peak at early light phase and a broad trough during the dark phase. This rhythm in the AVP contents was maintained even after 14 days of free-running under DD conditions and 3 days under LL conditions. These circadian patterns of AVP are similar to those of somatostatin, another peptide in the dorsomedial SCN. This indicates a common mode of regulation for peptides in this subfield of the SCN.
下丘脑前部的视交叉上核（SCN）包含哺乳动物的昼夜节律起搏器。我们测定了在光暗（LD）、持续黑暗（DD）和持续光照（LL）条件下大鼠中背内侧SCN的主要肽类——精氨酸加压素（AVP）的昼夜节律变化。在LD条件下，SCN中的AVP水平呈现昼夜节律性，在光照早期达到峰值，在黑暗期有一个较宽的低谷。即使在DD条件下自由运转14天和LL条件下3天后，AVP含量的这种节律仍得以维持。AVP的这些昼夜节律模式与背内侧SCN中的另一种肽——生长抑素的模式相似。这表明SCN这个亚区域中肽类的一种共同调节模式。
Zotero 插件