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口服双歧杆菌和乳酸杆菌对新生儿肠道的短暂定植。

Transient colonization of the gut of newborn infants by orally administered bifidobacteria and lactobacilli.

作者信息

Bennet R, Nord C E, Zetterström R

机构信息

Department of Paediatrics, S:t Göran's Children's Hospital, Stockholm, Sweden.

出版信息

Acta Paediatr. 1992 Oct;81(10):784-7. doi: 10.1111/j.1651-2227.1992.tb12103.x.

DOI:10.1111/j.1651-2227.1992.tb12103.x
PMID:1421883
Abstract

We investigated if orally administered bifidobacteria and/or lactobacilli could be cultured from faeces of infants after antibiotic treatment, when these bacterial species are usually absent. Lyophilized Bifidobacterium longum, strain BB-536, B. breve, strain BB-576, or Lactobacillus acidophilus, strain LAC-343, were used. Doses of 3 x 10(9) cells of one strain, or a mixture of all three strains 3 x 10(9) cells each were fed three times daily at mealtimes to 11 infants aged 0-8 weeks. Treatment was started the first day after antibiotic treatment and was continued for 5 days. The bacterial species were isolated in 9 of 11, 7 of 10 and 2 of 9 specimens obtained on the last day of bifidobacteria or lactobacilli administration, 5 and 15 days thereafter, respectively. No side effects were noted.

摘要

我们研究了在抗生素治疗后,通常不存在双歧杆菌和/或乳酸杆菌的婴儿粪便中,口服这些细菌后是否能够培养出来。使用了冻干的长双歧杆菌BB-536菌株、短双歧杆菌BB-576菌株或嗜酸乳杆菌LAC-343菌株。将一种菌株的3×10⁹个细胞剂量,或三种菌株的混合物各3×10⁹个细胞,在进餐时间每天喂给11名0至8周龄的婴儿三次。治疗在抗生素治疗后的第一天开始,并持续5天。在服用双歧杆菌或乳酸杆菌的最后一天、之后5天和15天分别采集的11份标本中的9份、10份标本中的7份和9份标本中的2份中分离出了这些细菌物种。未观察到副作用。

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引用本文的文献

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Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F167-73. doi: 10.1136/fn.80.3.f167.
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Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial.对早产儿早期给予短双歧杆菌:随机对照试验。
Arch Dis Child Fetal Neonatal Ed. 1997 Mar;76(2):F101-7. doi: 10.1136/fn.76.2.f101.
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Resistance of Bifidobacteria and Lactobacilli to tobramycin.双歧杆菌和乳酸杆菌对妥布霉素的耐药性。
Eur J Pediatr. 1996 May;155(5):421. doi: 10.1007/BF01955278.