接受光疗和维生素E治疗的新生儿外周淋巴细胞中的姐妹染色单体交换

Sister chromatid exchanges in peripheral lymphocytes in newborns treated with phototherapy and vitamin E.

作者信息

Galla A, Kitsiou-Tzeli S, Gourgiotis D, Hadjigeorgiou E, Yousef-Ayash H, Kanarios J, Richardson K, Sinaniotis C

机构信息

2nd Department of Pediatrics, University of Athens, P&A Kyriakou Children's Hospital, Greece.

出版信息

Acta Paediatr. 1992 Oct;81(10):820-3. doi: 10.1111/j.1651-2227.1992.tb12110.x.

DOI:10.1111/j.1651-2227.1992.tb12110.x

PMID:1421889

Abstract

A study was undertaken to determine whether blue fluorescent light might affect the sister chromatid exchange (SCE) frequency of peripheral lymphocytes in icteric newborns undergoing continuous phototherapy treatment (72 h). Also, the potential preventive effect of vitamin E on SCE frequency was studied in a subgroup of 11 preterm and 9 fullterm newborns after daily administration of vitamin E (46.44 mumol/kg/d, im). The results revealed that only the preterm icteric newborns showed an increase in mean SCE frequency of peripheral lymphocytes after phototherapy (9%, p = 0.02), but in no case did the highest SCEs/cell ratio exceed the normal values. No correlation was found between the average SCE rate and birth weight, gestational age or bilirubin levels. Also, no difference in SCEs was observed between newborns treated or untreated with vitamin E.

摘要

开展了一项研究，以确定蓝色荧光灯是否会影响接受持续光疗治疗（72小时）的黄疸新生儿外周淋巴细胞的姐妹染色单体交换（SCE）频率。此外，在11例早产儿和9例足月儿组成的亚组中，研究了每日给予维生素E（46.44 μmol/kg/d，肌肉注射）后，维生素E对SCE频率的潜在预防作用。结果显示，仅早产黄疸新生儿在光疗后外周淋巴细胞的平均SCE频率增加（9%，p = 0.02），但最高SCEs/细胞比值在任何情况下均未超过正常值。未发现平均SCE率与出生体重、胎龄或胆红素水平之间存在相关性。此外，在接受或未接受维生素E治疗的新生儿之间，未观察到SCEs有差异。