Tsai F J, Tsai C H, Peng C T, Wang T R
Department of Pediatrics and Medical Research, China Medical College Hospital, Taichung, Taiwan.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1998 Sep-Oct;39(5):327-9.
The frequency of sister chromatid exchange (SCE) was determined in newborn infants given phototherapy for more than five days, then determined again one year later. There were 8 healthy newborn infants and 15 icterus infants; 8 of these were treated with phototherapy for more than 5 days and the other 7 were not. In the follow-up study, 6 treated infants were evaluated. The results revealed that there was an increase in mean SCE frequency of peripheral lymphocytes after phototherapy, which reversed itself one year after treatment discontinuation. Prolonged continuous phototherapy may be responsible for the increase observed in SCEs in Chinese newborn.
测定了接受光疗超过五天的新生儿的姐妹染色单体交换（SCE）频率，一年后再次进行测定。有8名健康新生儿和15名黄疸婴儿；其中8名接受了超过5天的光疗，另外7名未接受光疗。在随访研究中，对6名接受治疗的婴儿进行了评估。结果显示，光疗后外周淋巴细胞的平均SCE频率增加，在停止治疗一年后恢复到原来水平。长时间持续光疗可能是中国新生儿中观察到的SCE增加的原因。
