铬酸铜（II）和重铬酸盐与多吡啶配合物的诱变活性

Mutagenic activity of copper(II) chromate and dichromate complexes with polypyridines.

作者信息

Szyba K, Golonka M C, Gasiorowski K, Urban J

机构信息

Department of Basic Medical Sciences, Medical Academy, Wrocław, Poland.

出版信息

Biometals. 1992 Autumn;5(3):157-61. doi: 10.1007/BF01061322.

DOI:10.1007/BF01061322

PMID:1421966

Abstract

Copper(II) chromate and dichromate complexes with 2,2'-bipyridyl and 1,10-phenathroline were tested for their mutagenic activity in the standard Ames test. All of six tested complexes exhibited markedly lower mutagenic activity than the reference compounds--potassium dichromate and sodium chromate. The blockage of Cr(VI) reduction capability in the presence of the complex Cu2+ ion and the competition between copper and chromium ions in the interaction with cellular components are discussed in the light of the results of our previous chemical study.

摘要

对铬酸铜（II）和重铬酸铜与2,2'-联吡啶及1,10-菲啰啉形成的配合物进行了标准艾姆斯试验以检测其诱变活性。所测试的六种配合物的诱变活性均明显低于参考化合物——重铬酸钾和铬酸钠。根据我们之前化学研究的结果，讨论了在配合物铜离子存在下六价铬还原能力的受阻以及铜离子与铬离子在与细胞成分相互作用中的竞争情况。