Robbins M E, Barnes D W, Hopewell J W, Knowles J F, Rezvani M, Sansom J M
Research Institute (University of Oxford), Churchill Hospital, UK.
Br J Radiol. 1992 Oct;65(778):910-7. doi: 10.1259/0007-1285-65-778-910.
The right kidney of female Large White pigs, approximately 14 weeks old, was irradiated with fractionated doses of fast neutrons (42 MeVd-->Be). The total doses used were 6.6-9.2 Gy. Changes in kidney function, assessed as the functional index (FI, where FI = irradiated kidney function/unirradiated kidney function) or as individual kidney glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), were serially determined up to 104 weeks after irradiation using 99Tcm-DTPA and 131I-hippuran renography. The animals were then euthanized, the kidneys removed and weighed. A dose-dependent reduction in FI was seen within 13 weeks of irradiation. Measuring individual kidney function revealed a hyperaemic response in both irradiated and unirradiated kidney 4 weeks after irradiation. This was followed by a dose-dependent reduction in irradiated kidney GFR and particularly ERPF. The ED50 value for the impairment in ERPF, assessed as the percentage of irradiated kidneys exhibiting a > or = 50% reduction in ERPF, was significantly lower than that for GFR, i.e. 7.20 +/- 0.10 Gy compared with 8.44 +/- 0.07 Gy (p < 0.001). A dose-related reduction in irradiated kidney weight was also observed. These fast neutron-induced changes in renal function and weight are qualitatively similar to those observed following photon irradiation of the pig kidney.
对大约14周龄的雌性大白猪的右肾进行了分次快速中子（42 MeVd→Be）照射。使用的总剂量为6.6 - 9.2 Gy。在照射后长达104周的时间里，使用99Tcm - DTPA和131I - 马尿酸肾造影术连续测定肾功能的变化，以功能指数（FI，其中FI = 照射肾的功能/未照射肾的功能）或单个肾的肾小球滤过率（GFR）和有效肾血浆流量（ERPF）来评估。然后对动物实施安乐死，取出肾脏并称重。照射后13周内观察到FI呈剂量依赖性降低。测量单个肾功能发现，照射后4周，照射肾和未照射肾均出现充血反应。随后，照射肾的GFR，尤其是ERPF呈剂量依赖性降低。以ERPF降低≥50%的照射肾的百分比来评估，ERPF损伤的ED50值显著低于GFR的ED50值，即分别为7.20±0.10 Gy和8.44±0.07 Gy（p < 0.001）。还观察到照射肾重量呈剂量相关的降低。这些快速中子诱导的肾功能和重量变化在性质上与猪肾接受光子照射后观察到的变化相似。
