Robbins M E, Hopewell J W, Gunn Y
Radiother Oncol. 1985;4(2):143-51. doi: 10.1016/s0167-8140(85)80101-8.
The right kidney of 13 Large White female pigs was irradiated with single doses of 250 kV X-rays in the range 7-12.6 Gy. Sequential measurements of individual kidney glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were carried out by means of 99mTc-DTPA and 131I-hippuran renography for periods up to 24 weeks after irradiation. GFR levels increased in irradiated and unirradiated contralateral kidneys 2 weeks after treatment compared with age-matched controls. ERPF values exhibited a small increase in a proportion of animals. Renal function then declined in irradiated kidneys in a dose-dependent manner. A dose of 7 Gy resulted in a decline followed by subsequent recovery. After doses of greater than or equal to 8.8 Gy GFR and ERPF declined rapidly, reaching minimal levels by 6-12 weeks, the time depending on the dose. The reduction in ERPF was quantitatively greater than that for GFR. In animals receiving greater than 8.8 Gy the irradiated kidney contributed in the order of only 10% of the total ERPF. The reduction in GFR resulted in a prompt functional compensatory response in GFR in the unirradiated contralateral kidney. In terms of ERPF, a compensatory response was not evident until weeks 20-24. The results indicated that the radiation tolerance dose of the pig kidney following unilateral irradiation with single doses of X-rays was approximately 8 Gy.
对13头大白猪的右肾进行单剂量250 kV X射线照射，照射剂量范围为7 - 12.6 Gy。在照射后长达24周的时间内，通过99mTc - DTPA和131I - 马尿酸肾图对个体肾脏的肾小球滤过率（GFR）和有效肾血浆流量（ERPF）进行连续测量。与年龄匹配的对照组相比，照射后2周，照射侧和未照射的对侧肾脏的GFR水平均升高。部分动物的ERPF值略有升高。随后，照射侧肾脏的肾功能呈剂量依赖性下降。7 Gy的剂量导致肾功能下降，随后恢复。剂量大于或等于8.8 Gy时，GFR和ERPF迅速下降，在6 - 12周时达到最低水平，时间取决于剂量。ERPF的降低在数量上大于GFR。接受大于8.8 Gy照射的动物中，照射侧肾脏对总ERPF的贡献仅约为10%。GFR的降低导致未照射的对侧肾脏GFR出现迅速的功能代偿反应。就ERPF而言，直到20 - 24周才出现明显的代偿反应。结果表明，单剂量X射线单侧照射猪肾后的辐射耐受剂量约为8 Gy。
