Weis L, Reinberg D
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.
FASEB J. 1992 Nov;6(14):3300-9. doi: 10.1096/fasebj.6.14.1426767.
Studies of transcription by RNA polymerase II have revealed two promoter elements, the TATA motif and the initiator (Inr), capable of directing specific transcription initiation. Although binding to the TATA motif by one of the components of the transcription machinery has been shown to be the initial recognition step in transcription complex formation, many promoters that lack a traditional TATA motif have recently been described. In such TATA-less promoters, the Inr element is critical in positioning RNA polymerase II. Various Inr elements have been described and classified according to sequence homology. These Inr elements are recognized specifically by Inr-binding proteins. Interaction between these Inr-binding proteins and components of the basal transcription machinery provides a means through which a transcription competent complex can be formed.
对RNA聚合酶II转录的研究揭示了两种启动子元件，即TATA基序和起始子（Inr），它们能够指导特异性转录起始。尽管转录机制的一个组分与TATA基序的结合已被证明是转录复合物形成中的初始识别步骤，但最近已描述了许多缺乏传统TATA基序的启动子。在这种无TATA启动子中，Inr元件对于定位RNA聚合酶II至关重要。根据序列同源性已描述并分类了各种Inr元件。这些Inr元件被Inr结合蛋白特异性识别。这些Inr结合蛋白与基础转录机制的组分之间的相互作用提供了一种形成转录活性复合物的方式。
