氯喹治疗的眼部并发症
OCULAR COMPLICATIONS OF CHLOROQUINE THERAPY.
作者信息
LLOYD L A, HILTZ J W
出版信息
Can Med Assoc J. 1965 Mar 6;92(10):508-13.
Abstract
Ocular complications of long-term chloroquine therapy were observed in 18 of 45 patients so treated. This therapy was used in patients with rheumatoid arthritis, lupus erythematosus, sarcoidosis, discoid lupus and other chronic "collagen disease". Thirteen patients had reversible corneal opacifications, and seven had irreversible retinal changes, with visual loss and visual field defects. Pathological evidence of chloroquine retinopathy was obtained in one patient. Physicians are therefore warned to use this drug only after careful consideration. If it is used, repeated ocular examinations should include assessment of visual acuity, visual fields on a tangent screen and fundus examination through a dilated pupil.
摘要
在接受长期氯喹治疗的45例患者中，有18例出现了眼部并发症。该疗法用于类风湿性关节炎、红斑狼疮、结节病、盘状狼疮及其他慢性“胶原病”患者。13例患者出现可逆性角膜混浊，7例出现不可逆性视网膜改变，伴有视力丧失和视野缺损。1例患者获得了氯喹视网膜病变的病理证据。因此，告诫医生在仔细考虑后再使用此药。如果使用该药，反复的眼部检查应包括视力评估、切线屏视野检查以及散瞳后的眼底检查。
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