氯喹视网膜病变：是否存在安全的每日剂量？
Chloroquine retinopathy: is there a safe daily dose?
作者信息
Marks J S
出版信息
Ann Rheum Dis. 1982 Feb;41(1):52-8. doi: 10.1136/ard.41.1.52.
Abstract
Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less. Eleven cases of ocular toxicity attributed to chloroquine were reported to the Committee on Safety of Medicines but only 2 developed impaired vision on 250 mg daily. A postal questionnaire among 41 rheumatology and 33 ophthalmology centres showed 2 patients who developed impaired vision as a result of treatment with chloroquine in a daily dose not exceeding 250 mg. Serious visual impairment related to chloroquine rarely occurs if the daily dose does not exceed 250 mg.
摘要
已发表的氯喹视网膜病变病例报告很少包含每日剂量的详细信息，但在可获取该信息的30份报告中，有78名患者出现视力受损，其中13人每日服用剂量为250毫克或更低。有11例归因于氯喹的眼部毒性报告给了药品安全委员会，但只有2例每日服用250毫克时出现视力受损。对41个风湿病中心和33个眼科中心进行的邮政问卷调查显示，有2名患者因每日服用不超过250毫克的氯喹而出现视力受损。如果每日剂量不超过250毫克，与氯喹相关的严重视力损害很少发生。
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