Percival S P, Meanock I
Br Med J. 1968 Sep 7;3(5618):579-84. doi: 10.1136/bmj.3.5618.579.
272 patients on long-term chloroquine therapy were assessed with respect to ocular toxicity and clinical benefit. A simple scheme for rendering patients ophthalmologically safe is presented, employing the recording of central fields to red targets. Under this it was possible to diagnose a state of premaculopathy, which was reversible on stopping treatment. The incidence of premaculopathy was 41% in 143 patients who otherwise displayed no abnormality of the fundus oculi and who had received a mean total dose of 410 g. of chloroquine phosphate or the hydroxychloroquine sulphate equivalent. Under this joint ophthalmological and rheumatological supervision it was considered that the minor side-effects that may be caused by chloroquine are outweighed by its therapeutic value.
对272名接受长期氯喹治疗的患者进行了眼毒性和临床疗效评估。提出了一种使患者眼部安全的简单方案，即记录中心视野对红色目标的反应。据此可以诊断出黄斑前病变状态，这种病变在停止治疗后是可逆的。在143名患者中，黄斑前病变的发生率为41%，这些患者眼底无其他异常，平均总剂量为410克磷酸氯喹或等效的硫酸羟氯喹。在眼科和风湿病学的联合监督下，认为氯喹可能引起的轻微副作用与其治疗价值相比是微不足道的。
