MATHEWSON F A, BRERETON C C, KELTIE W A, PAUL G I
Can Med Assoc J. 1965 May 8;92(19):1002-6.
The relationship of selected physical and electrocardiographic factors to the occurrence of coronary heart disease was examined in a cohort of 3983 healthy North American males followed up for 15 years. Variations in build or mean heart rate were not found to be related to the occurrence of coronary heart disease. The risk of coronary heart disease rose progressively as blood pressure increased. With readings of 160/95 mm. Hg or higher the risk was 1.77 times that of the population as a whole. Non-specific S-T and/or T wave changes in the electrocardiogram were associated with three times the risk of developing coronary heart disease. Individuals with the combination of a blood pressure of 160/95 mm. Hg and nonspecific T wave changes exhibited an augmented susceptibility to coronary heart disease, the risk being four times that of the whole population.
在一个由3983名健康北美男性组成的队列中，对选定的身体因素和心电图因素与冠心病发生之间的关系进行了为期15年的随访研究。未发现体型或平均心率的变化与冠心病的发生有关。冠心病的风险随着血压升高而逐渐增加。血压读数为160/95毫米汞柱或更高时，风险是总体人群的1.77倍。心电图中的非特异性S-T段和/或T波改变与患冠心病风险增加三倍相关。血压为160/95毫米汞柱且伴有非特异性T波改变的个体对冠心病的易感性增强，风险是总体人群的四倍。
