MATHEWSON F A, BRERETON C C, KELTIE W A, PAUL G I
Can Med Assoc J. 1965 May 1;92(18):947-53.
A prospective study of cardiovascular disease was initiated in 1946 whereby 3983 healthy North American males, 91% under age 40, were subjected to periodic electrocardiograms and medical examinations between 1948 and 1963. The health of all but five of the 3773 survivors was known in 1963. There were 210 deaths: aircraft accidents accounted for 45%, cardiovascular disease 20%, cancer 11% and other causes 23%. The aggregate mortality closely resembled that of the Canadian Life Table 1955-57 (Male). Extra deaths were observed under age 40 owing to a high frequency of flying accidents. At older ages the mortality was lower than expected because congenital and chronic diseases were excluded at entry. One hundred and forty-three developed coronary heart disease. The case fatality rate was 31%. The incidence rate for coronary heart disease rose progressively from 0.277 per thousand per year for ages 25-34 to 26.5 at ages 60-69.
1946年启动了一项心血管疾病前瞻性研究，对3983名健康的北美男性进行研究，其中91%年龄在40岁以下，在1948年至1963年间接受定期心电图检查和医学检查。1963年时，除5人外，3773名幸存者的健康状况均已知晓。共有210人死亡：飞机事故占45%，心血管疾病占20%，癌症占11%，其他原因占23%。总死亡率与《1955 - 57年加拿大人寿表（男性）》极为相似。由于飞行事故发生率高，40岁以下人群出现了额外死亡。在较高年龄段，死亡率低于预期，因为入组时排除了先天性和慢性疾病。有143人患冠心病，病死率为31%。冠心病发病率从25 - 34岁年龄段的每年千分之0.277逐步上升至60 - 69岁年龄段的26.5。
