Kannel W B, Anderson K, McGee D L, Degatano L S, Stampfer M J
Am Heart J. 1987 Feb;113(2 Pt 1):370-6. doi: 10.1016/0002-8703(87)90280-8.
The risk of developing overt coronary heart disease is examined in relation to occurrence of non-specific electrocardiographic S-T and T-wave abnormalities (NSA-ECG) in the Framingham Study. In the course of follow-up, 14% of the 5127 men and women had or developed NSA-ECG without clinically apparent intervening coronary heart disease. During 30 years of surveillance, 760 men and 578 women developed a first overt clinical manifestation of coronary heart disease. NSA-ECG appears to be a hallmark of a compromised coronary circulation which predicted the occurrence of every clinical manifestation of coronary heart disease independently of known risk factors including hypertension, its chief determinant. Coronary morbidity and mortality was increased twofold in each sex. The more common T-wave abnormality alone carried a significant increased risk, although the combination of S-T and T-wave seemed most hazardous. Persons who develop NSA-ECG without other explanation warrant vigorous preventive management against coronary heart disease.
在弗明汉姆研究中，研究了非特异性心电图S-T段和T波异常（NSA-ECG）的出现与显性冠心病发生风险之间的关系。在随访过程中，5127名男性和女性中有14%出现或发生了NSA-ECG，且无临床上明显的介入性冠心病。在30年的监测期间，760名男性和578名女性出现了冠心病的首次显性临床表现。NSA-ECG似乎是冠状动脉循环受损的一个标志，它独立于包括高血压（其主要决定因素）在内的已知风险因素，预测了冠心病的每一种临床表现的发生。每种性别的冠心病发病率和死亡率都增加了两倍。仅较常见的T波异常就带来了显著增加的风险，尽管S-T段和T波异常同时出现似乎风险最大。在没有其他解释的情况下出现NSA-ECG的人需要积极采取针对冠心病的预防管理措施。
