Requena L, Gutiérrez J, Sánchez Yus E
Department of Dermatology, San Carlos University Hospital, Complutense University, Madrid, Spain.
J Cutan Pathol. 1992 Aug;19(4):346-51. doi: 10.1111/j.1600-0560.1992.tb01373.x.
Multiple hamartoma syndrome, or Cowden's disease, is a rare genodermatosis with multiple organ system involvement in which malignancy, particularly of breast and thyroid, may develop. Multiple trichilemmomas have been classically regarded as the cutaneous hallmark of this disease. We here emphasize multiple sclerotic fibromas of the skin as another specific cutaneous marker of this entity, which may also be helpful in an early diagnosis.
多发性错构瘤综合征，即考登病，是一种罕见的遗传性皮肤病，可累及多个器官系统，可能会发生恶性肿瘤，尤其是乳腺癌和甲状腺癌。多发性毛发上皮瘤一直被视为该病的皮肤特征。我们在此强调皮肤多发性硬化性纤维瘤是该疾病的另一种特异性皮肤标志物，这也可能有助于早期诊断。
