Metcalf J S, Maize J C, LeBoit P E
Department of Dermatology, Medical University of South Carolina, Charleston 29425.
Am J Dermatopathol. 1991 Apr;13(2):122-9. doi: 10.1097/00000372-199104000-00004.
In the past several years we have examined eight dermal nodules that have morphologic features identical to the nodules described in patients with Cowden's disease. The patients in this series had no other clinical manifestations of Cowden's disease. In an attempt to better define this distinctive entity, we subjected tissue sections to a battery of histochemical and immunohistochemical stains and examined tissue from one of the nodules ultrastructurally. Although we found similarities between these nodules and other common dermal fibrotic lesions, we believe that they are distinctive architecturally (they are sharply circumscribed and have a strikingly uniform storiform pattern) and immunohistochemically (with uniformly scattered factor 13a-positive cells). Because of the unique histologic features, we propose that the term "circumscribed storiform collagenoma" be applied to these nodules.
在过去几年中，我们检查了8个皮肤结节，其形态学特征与考登病患者所描述的结节相同。该系列患者无考登病的其他临床表现。为了更好地界定这一独特实体，我们对组织切片进行了一系列组织化学和免疫组织化学染色，并对其中一个结节的组织进行了超微结构检查。尽管我们发现这些结节与其他常见的皮肤纤维化病变有相似之处，但我们认为它们在结构上（边界清晰，具有显著一致的席纹状模式）和免疫组织化学上（有均匀散在的因子13a阳性细胞）具有独特性。由于其独特的组织学特征，我们建议将这些结节称为“局限性席纹状胶原瘤”。
