Kennedy G L, Banerjee A K
Haskell Laboratory for Toxicology and Industrial Medicine, Du Pont Central Research and Development, Newark, DE.
J Appl Toxicol. 1992 Aug;12(4):281-4. doi: 10.1002/jat.2550120412.
A series of 76 fiber finishes, typically composed of blends of lubricants, emulsifiers, antistatic agents and fatty acid soaps, were tested in rabbits to determine both the eye and the skin irritation potential. Each finish was classified as being either non-, slightly, mildly, moderately or severely irritating to the target tissue during a 48-h post-treatment period. Seven (9.2%) of the finishes tested were severely irritating to both the skin and the eye; two (2.6%) were determined to be non-irritating to both tissues. While occasionally finishes produced equal degrees of damage resulting in similar irritancy classifications, seven (9.2%) finishes were found to be severely irritating to the skin without producing any irritation in the eye. Conversely, one finish was found to be a severe eye irritant without producing any skin irritation. The suggested use of the skin irritation data to predict the ocular reaction needs to be carefully examined, particularly with materials such as these fiber finishes. The prediction that a severe skin irritant is also a severe eye irritant was demonstrated to be in error with 8 of 75 (10.5%) of the finishes studied. Further, there is little predictive association between the skin and eye irritation for these compounds.
对一系列76种纤维整理剂进行了兔体试验，这些整理剂通常由润滑剂、乳化剂、抗静电剂和脂肪酸皂混合而成，以确定其对眼睛和皮肤的潜在刺激性。在处理后的48小时内，每种整理剂根据对目标组织的刺激程度分为无刺激、轻微刺激、轻度刺激、中度刺激或重度刺激。所测试的整理剂中，有7种（9.2%）对皮肤和眼睛均有严重刺激；2种（2.6%）对两种组织均无刺激。虽然偶尔会出现整理剂造成同等程度的损伤从而导致相似的刺激分类，但有7种（9.2%）整理剂对皮肤有严重刺激，而对眼睛无任何刺激。相反，有一种整理剂被发现是严重的眼部刺激物，而对皮肤无任何刺激。利用皮肤刺激数据来预测眼部反应的建议需要仔细研究，尤其是对于这些纤维整理剂这类材料。在研究的75种整理剂中，有8种（10.5%）表明，预测严重的皮肤刺激物也是严重的眼部刺激物是错误的。此外，这些化合物的皮肤刺激和眼睛刺激之间几乎没有预测关联。
