Hansen R L, Evans A T, Gillogley K M, Hughes C S, Krener P G
Department of Pediatrics, University of California, Davis School of Medicine.
J Perinatol. 1992 Sep;12(3):220-4.
Accurate identification of substance abusing mothers and their infants is critical for appropriate medical management as well as the collection of accurate information on the effects of illicit drug use on perinatal morbidity, mortality, and long-term neurobehavioral outcome in the infants. This study examines the differences found using two methods for urine toxicology screening at the time of obstetrical admission to the hospital. The institution of universal screening identified significantly more women than were previously identified through the use of a risk-directed protocol (P less than .0001). Women identified using either protocol were significantly more likely than toxicology-negative women to have had poor prenatal care and to have smoked and used alcohol during pregnancy (P less than .001). In the population studied, the multiple criteria needed to accurately identify mothers with positive-toxicology screens would also include screening over one half of the toxicology-negative mothers.
准确识别滥用药物的母亲及其婴儿对于适当的医疗管理以及收集关于非法药物使用对围产期发病率、死亡率和婴儿长期神经行为结局影响的准确信息至关重要。本研究考察了在产科入院时使用两种尿液毒理学筛查方法所发现的差异。普遍筛查制度识别出的女性比之前通过风险导向方案识别出的显著更多（P小于0.0001）。使用任一方案识别出的女性比毒理学阴性的女性更有可能在孕期接受的产前护理较差，且有吸烟和饮酒行为（P小于0.001）。在所研究的人群中，准确识别毒理学筛查呈阳性的母亲所需的多个标准还将包括对超过一半毒理学阴性的母亲进行筛查。
