Lacroix P, Linée P, Le Pollès J B
C R Seances Soc Biol Fil. 1977;171(1):214-7.
From lower concentrations (from 10(-7) to 10(-5) M) ethaverine reduces the maximal following frequency (MFF) of isolated guinea-pig's right atrium during its electrical driving at increasing frequencies. On the other hand, papaverine assumes a variable effect according to its concentration: increase (10(-7) M) or decrease (10(-6) M) of MFF. Modifications of MFF are related with those of atrial effective refractory period (ERP). These results show that ethaverine induces a lengthening of ERP whereas papaverine reduces or increases ERP. These observations are discussed comparatively with previous personal data on anesthetized dogs (Lacroix et al.) and with local anesthetic properties of ethaverine.
在较低浓度（10⁻⁷至10⁻⁵M）下，依沙维林在以递增频率对离体豚鼠右心房进行电驱动时，会降低其最大跟随频率（MFF）。另一方面，罂粟碱根据其浓度产生不同的效应：MFF增加（10⁻⁷M）或降低（10⁻⁶M）。MFF的改变与心房有效不应期（ERP）的改变相关。这些结果表明，依沙维林可使ERP延长，而罂粟碱则使ERP缩短或延长。将这些观察结果与之前关于麻醉犬的个人数据（拉克鲁瓦等人）以及依沙维林的局部麻醉特性进行了比较讨论。
