Lacroix P, Linee P, Quiniou P, Polles J P
Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76.
Ethaverine inhibits both atrioventricular conduction and heart rate, starting at a dosage of 1 mg/kg, injected i.v. into the anaesthetized dog. In the experimental conditions used, ethaverine is clearly different from papaverine, which stimulates both at a dosage between 1 and 10 mg/kg, and which only produces an inhibitory effect starting at a dosage of 20 mg/kg, with the appearance of cardiotoxic phenomena. After total cardiac denervation the inhibitory action of ethaverine persists partially, especially at the atrioventricular level, which is probably due to a direct effect on the heart muscle. The observed differences can hardly be explained by a more pronounced cardiac toxicity. Consequently, the ethyl-derivative of papaverine constitutes, in certain aspects, a molecule with original pharmacological properties.
依托维林抑制房室传导和心率，静脉注射给麻醉犬时，从1毫克/千克的剂量开始起作用。在所使用的实验条件下，依托维林明显不同于罂粟碱，罂粟碱在1至10毫克/千克的剂量之间会产生刺激作用，仅在20毫克/千克的剂量开始时才产生抑制作用，并伴有心脏毒性现象。完全心脏去神经支配后，依托维林的抑制作用部分持续存在，尤其是在房室水平，这可能是由于对心肌的直接作用。观察到的差异很难用更明显的心脏毒性来解释。因此，罂粟碱的乙基衍生物在某些方面构成了一个具有独特药理特性的分子。
