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纽约州的经皮腔内冠状动脉成形术。危险因素与预后。

Percutaneous transluminal coronary angioplasty in New York State. Risk factors and outcomes.

作者信息

Hannan E L, Arani D T, Johnson L W, Kemp H G, Lukacik G

机构信息

Department of Health Policy and Management, State University of New York, Albany.

出版信息

JAMA. 1992 Dec 2;268(21):3092-7.

PMID:1433740
Abstract

OBJECTIVE

To identify significant independent risk factors for major percutaneous transluminal coronary angioplasty outcomes.

DESIGN

Retrospective analysis using univariate and logistic regression analysis to identify significant independent risk factors for adverse outcomes.

SETTING

All 31 hospitals performing percutaneous transluminal coronary angioplasty in New York State in 1991.

PATIENTS

All 5827 patients undergoing percutaneous transluminal coronary angioplasty between January 1, 1991, and June 30, 1991, in New York State.

MAIN OUTCOME MEASURES

In-hospital mortality, major complication(s) (in-hospital mortality, myocardial infarction, and/or emergency coronary artery bypass graft), and absence of angiographic success (stenosis reduction of less than 20% on any attempted lesion or residual stenosis of at least 50% on any attempted lesion).

MAIN RESULTS

Before discharge from the hospital, a total of 37 patients (0.63%) died; 67 patients (1.1%) suffered a myocardial infarction, with a mortality rate of 4.5%; and 97 patients (1.7%) underwent emergency coronary artery bypass graft surgery, with a mortality rate of 2.1% (no deaths in 85 patients who were hemodynamically stable and two deaths among 12 patients who were hemodynamically unstable). A total of 187 patients (3.2%) experienced a major complication. Angiographic success was achieved for 88% of all patients. Multivariate analysis found four independent preprocedural variables related to death: female gender, hemodynamic instability, shock, and ejection fraction.

CONCLUSIONS

Percutaneous transluminal coronary angioplasty outcomes in New York compare favorably with other recent results reported in the literature. Several preprocedural variables markedly increase the incidence of adverse events.

摘要

目的

确定主要经皮冠状动脉腔内血管成形术(PTCA)结果的显著独立危险因素。

设计

采用单因素和逻辑回归分析进行回顾性分析,以确定不良结果的显著独立危险因素。

地点

1991年在纽约州进行经皮冠状动脉腔内血管成形术的所有31家医院。

患者

1991年1月1日至1991年6月30日在纽约州接受经皮冠状动脉腔内血管成形术的所有5827例患者。

主要观察指标

住院死亡率、主要并发症(住院死亡率、心肌梗死和/或急诊冠状动脉搭桥术)以及血管造影未成功(任何尝试病变处狭窄减少小于20%或任何尝试病变处残余狭窄至少50%)。

主要结果

出院前,共有37例患者(0.63%)死亡;67例患者(1.1%)发生心肌梗死,死亡率为4.5%;97例患者(1.7%)接受急诊冠状动脉搭桥术,死亡率为2.1%(血流动力学稳定者85例无死亡,血流动力学不稳定者12例中有2例死亡)。共有187例患者(3.2%)发生主要并发症。所有患者中88%血管造影成功。多因素分析发现与死亡相关的四个术前独立变量:女性、血流动力学不稳定、休克和射血分数。

结论

纽约州经皮冠状动脉腔内血管成形术的结果与文献中最近报道的其他结果相比具有优势。几个术前变量显著增加不良事件的发生率。

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