Petr T, Bárta I, Adámková M, Hrabal P
National Institute of Public Health, Prague, Czechoslovakia.
Neoplasma. 1992;39(4):241-4.
The influence of partial hepatectomy (PH) on the genotoxic effect of aflatoxin B1 (AFB1) mycotoxin in male Chinese hamsters (Cricetulus griseus) in vivo was studied after a repeated i.p. application of small doses of AFB1 during 8 weeks. The frequency of aberrant cells did not increase after repeated application and persisted throughout the whole period on a relatively stable level. No cumulative genotoxic effect of repeated doses of AFB1 was observed. PH decreased the genotoxic effect of AFB1 only in week 4, while in weeks 6 and 8 no significant differences between hepatectomized and nonhepatectomized animals were recorded.
在8周内对雄性中国仓鼠（黑线仓鼠）反复腹腔注射小剂量黄曲霉毒素B1（AFB1）后，研究了部分肝切除术（PH）对AFB1霉菌毒素体内遗传毒性作用的影响。反复注射后异常细胞的频率没有增加，并且在整个期间一直维持在相对稳定的水平。未观察到重复剂量AFB1的累积遗传毒性作用。PH仅在第4周降低了AFB1的遗传毒性作用，而在第6周和第8周，肝切除动物和未肝切除动物之间未记录到显著差异。
