Petr T, Bárta I, Turek B
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
J Hyg Epidemiol Microbiol Immunol. 1990;34(2):123-8.
Experiments were carried out to verify the effect of selenium on the mutagenic activity of AFB1. After 14 days of selenium administration to experimental animals (Chinese hamsters, Cricetulus griseus) in the form of 2 ppm Na2SeO3 solution available ad libitum the incidence of chromosomal aberrations in bone marrow cells due to a single p.o. administration of 5 mg AFB1 per 1 kg body weight was significantly reduced. The incidence of chromosomal aberrations was monitored till day 32 after AFB1 administration. A significant decrease in the frequency of aberrant cells, breaks and gaps was observed at almost any time during the investigation. 2 ppm Na2SeO3 solution itself did not enhance the frequency of chromosomal aberrations. The mechanism of the protective effect of selenium vis-a-vis the mutagenic and carcinogenic action of AFB1 remains obscure.
进行实验以验证硒对黄曲霉毒素B1致突变活性的影响。以2 ppm的亚硒酸钠溶液形式，让实验动物（中国仓鼠，黑线仓鼠）自由饮用14天硒后，每1千克体重单次口服5毫克黄曲霉毒素B1导致的骨髓细胞染色体畸变发生率显著降低。在给予黄曲霉毒素B1后直至第32天监测染色体畸变发生率。在调查期间的几乎任何时候都观察到异常细胞、断裂和间隙的频率显著降低。2 ppm的亚硒酸钠溶液本身并未提高染色体畸变频率。硒对黄曲霉毒素B1的致突变和致癌作用的保护机制仍不清楚。
