Naumenko E V, Shishkina G T
Probl Endokrinol (Mosk). 1977 Mar-Apr;23(2):75-8.
Intraperitoneal administration of 5-oxytryptophane or the administration of serotonin into the lateral ventricle of the brain to the unilaterally castrated male albino rats was accompanied by block of the compensatory increase of the testosterone level in the peripheral blood plasma occurring after its fall caused by hemicastration. Under analogous conditions the intraperitoneal administration of p-chlorphenylalanine or the intraventricular administration of methisergide intensified the compensatory increase of blood testosterone after castration. A conclusion was drawn that stimulation of the serotonin receptors of the brain produced an inhibitory influence on the central negative feed-back mechanisms in the hypothalamus-hypophysis-testes system.
对单侧去势的雄性白化大鼠腹腔注射5-羟色氨酸或向其脑侧脑室注射血清素，会阻碍外周血浆睾酮水平因半侧去势下降后出现的代偿性升高。在类似条件下，腹腔注射对氯苯丙氨酸或脑室内注射麦角新碱会增强去势后血液睾酮的代偿性升高。由此得出结论，刺激脑内的血清素受体会对下丘脑-垂体-睾丸系统中的中枢负反馈机制产生抑制作用。
